GREAT ADVANCES HAVE BEEN ACHIEVED IN RECENT DECADES TOWARD THE DEVELOPMENT OF HEAVY METALLIC NANOCLUSTERS BECAUSE ARE ISOLATED PARTICLES THAT ARE BRIDGING THE GAP BETWEEN TRADITIONAL ORGANOMETALLIC COMPOUNDS AND CRYSTALLINE METAL NANOPARTICLES [1, 2]. AS WELL AS HAVE THEIR UNIQUE PROPERTIES THAT DIFFER SUBSTANTIALLY FROM THOSE OF THE CORRESPONDING ATOMS AND BULK MATERIALS. OWING TO THEIR ULTRASMALL SIZE, GOOD BIOCOMPATIBILITY, HIGH STABILITY AND LUMINESCENT PROPERTIES METAL NANOCLUSTERS EXHIBIT FOR A VARIETY OF BIOMEDICAL AND CATALYSIS APPLICATIONS [3]. IN PREVIOUS YEARS REPORTED CONTROLLING OF SIZES OF COPPER METALLIC CLUSTERS.HOWEVER, TO DATE, ONLY A FEW STUDIES HAVE GIVEN DIRECT INSIGHT INTO COPPER NANOCLUSTERS BECAUSE OF THE DIFFICULTY IN PREPARING STABLE AND HIGHLY LUMINESCENT CU PARTICLES [4]. THIS IS RATHER SURPRISING AS CU (0) NANOCLUSTERS CAN REPLACE OTHER NOBLE METAL NANOCLUSTERS SUCH AS AG, AU AND PT NANOCLUSTERS. IN ADDITION TO THE ABOVE FEATURES FOR METAL NANOCLUSTERS, SOME SUPERIOR PROPERTIES SUCH AS LOW TOXICITY, ENVIRONMENTALLY AND MULTI-FUNCTIONAL SURFACE CHEMISTRY MAKE CU NANOCLUSTERS RECEIVE MUCH ATTENTION IN THE BIOLOGICAL AND CATALYSIS FIELDS [5, 6]. IN THIS STUDY, COPPER SALT HAS BEEN REDUCED BY HYDRAZINE HYDRATE IN THE PRESENCE OF PROTEIN AS A STABILIZING LIGAND AT ROOM TEMPERATURE. THE WATER SOLUBLE COPPER NANOCLUSTERS WAS SYNTHESIZED AND IDENTIFIED BY XPS, TEM, ICP, ATOMIC ABSORPTION, FT-IR AND PHOTOLUMINESCENCE. THE SPHERICAL CU PARTICLES WITH A MEAN DIAMETER OF 3±0.5 NM ARE OBSERVED BY TEM IMAGES INDICATING A RELATIVELY HIGH MONODISPERSITY OF CU NANOCLUSTERS IN THE SYSTEM. ALSO CU CONTENT DETERMINED BY ICP IS ABOUT 292.49 PPM.